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SUMMARY:MAX4Life Talk: Watching enzymes at work: tools for time-resolved s
 erial synchrotron crystallography
DTSTART:20260320T123000Z
DTEND:20260320T133000Z
DTSTAMP:20260606T165500Z
UID:indico-event-5879@indico.maxiv.lu.se
DESCRIPTION:Warm welcome to Dr. Eike C. Schulz as our first speaker in the
  MAX4Life Talk Series for Spring 2026!\nThe MAX4Life series highlights inn
 ovative and impactful Life Science research through roughly one-hour talks
 \, followed by Q&A and informal mingling with the MAX IV community.\nTalk 
 Title: Watching enzymes at work: tools for time-resolved serial synchrotro
 n crystallography\nSpeaker: Eike C. Schulz\, ERC Investigator\, BMBF Grou
 p Leader\, UKE Hamburg\nTime & Date: 13:30 to 14:30\, Friday\, March 20\nL
 ocation: meeting room MAX III\, MAX IV Laboratory\nRegistration: Registrat
 ion is for individuals who are not affiliated with MAX IV and would like t
 o attend the talk in person at the MAX IV facility. It is free of charge\n
 Deadline for registration: 11:30 am Thursday\, March 19\nPlease use the Zo
 om Link if attending remotely.\nAbstract:\nEike’s talk will present how 
 modern time resolved serial synchrotron crystallography (TR SSX) allows re
 searchers to watch enzymes in action by capturing their structural dynamic
 s during catalysis. Using innovative methods such as the hit and return (H
 ARE) and liquid application (LAMA) techniques\, reactions can be triggered
  inside protein crystals and followed across biologically relevant timesca
 les. These approaches have revealed unprecedented insight into enzyme beha
 vior\, including “molecular breathing\,” half the sites reactivity\, a
 nd intermediate ligand binding states\, phenomena invisible to traditional
  static structural methods. Recent developments\, including the spitrobot 
 and temperature controlled multi dimensional crystallography\, now make th
 ese once complex experiments simpler and accessible to a wider scientific 
 community.Because antibiotic resistance is tightly linked to enzyme motion
 \, TR SSX provides critical information for identifying new allosteric sit
 es and designing more robust inhibitors. Together\, these tools are reshap
 ing our understanding of enzyme mechanisms and opening new directions for 
 combating antimicrobial resistance\nMore information here: Schulz Group\nA
 bout the Speaker:\n\n\nDr. Eike Schulz’s research focuses on the molecul
 ar structure and dynamics of enzymes involved in infection processes. His 
 work spans two major research initiatives:\n\nANTIBIOTIMEX – investigati
 ng the molecular mechanisms of antibiotic‑resistance enzymes.\nDynaPLIX 
 – exploring the dynamic process of ligand binding to proteins through an
  integrated structural\, kinetic\, and thermodynamic approach.\n\nHis rese
 arch provides key insights into enzyme function and resistance mechanisms\
 , supporting the development of future therapeutic strategies.\n\n\n \n\n
  \n\nhttps://indico.maxiv.lu.se/event/5879/
LOCATION:MAX III (MAX IV)
URL:https://indico.maxiv.lu.se/event/5879/
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