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Warm welcome to Farangis Foroughi as our second speaker in the MAX4Life Talk Series for autumn 2025!
The MAX4Life series highlights innovative and impactful Life Science research through roughly one-hour talks, followed by Q&A and informal mingling with the MAX IV community.
Talk Title: Low-Dose In Vivo Lung Imaging Using X-ray Multiple-Image Radiography (MIR): Bridging MIR with Histology
Speaker: Farangis Foroughi, PhD candidate, Double-degree program between University of Saskatchewan (Canada) and Mid Sweden University (Sweden)
Time & Date: 13:00 to 13:45, Thursday, 4th December
Location: meeting room MAX III, MAX IV Laboratory
Registration: Registration is for individuals who are not affiliated with MAX IV and would like to attend the talk in person at the MAX IV facility. It is free of charge
Deadline for registration: 11:30 am Wednesday, 3rd December
Please use the Zoom Link if attending remotely.
Abstract:
Multiple-Image Radiography (MIR) is a phase-contrast X-ray technique that simultaneously provides absorption, refraction, and ultra-small-angle scattering (USAXS) information, offering exceptional sensitivity to microscopic variations in soft tissue. This presentation outlines recent progress in applying MIR for quantitative, low-dose in vivo lung imaging, supported by developments in the new MIR2 analysis framework.
MIR2 introduces an integrated angular calibration based on the dynamical theory of diffraction, combined with pixel-wise Gaussian fitting of object and reference datasets processed independently. This approach eliminates the need for normalization, mitigates alignment artifacts, and enables more robust and reproducible extraction of MIR contrast channels.
Using MIR at the BMIT beamline of the Canadian Light Source, a live mouse lung was imaged. The results demonstrate clear visualization of lung microstructure with reduced artifacts and enhanced signal stability across stitched fields of view.
The talk will further explore ongoing work on bridging MIR with histology, aiming to model how air–tissue interface density governs MIR-derived contrasts. This correlation provides a path toward quantitative interpretation of MIR data and establishes MIR as a non-destructive, low-dose imaging method for assessing lung health and microstructure.
Reference:
Foroughi, Farangis, Gurpreet Kaur Aulakh, David Krapohl, Börje Norlin, Ralf Hendrik Menk, and Dean Chapman. "A Gaussian fitting-based analysis method for multiple image radiography with integrated angular calibration, MIR2." Physics in Medicine and Biology (2025).
About the Speaker
Farangis Foroughi, is a PhD candidate in a double-degree program between the University of Saskatchewan (Canada) and Mid Sweden University (Sweden). Her research focuses on X-ray imaging, particularly biomedical imaging using analyzer-based techniques such as MIR. She also works on X-ray fluorescence (XRF) for paper-industry research, exploring elemental mapping and material characterization. Her work combines synchrotron-based imaging, histology, and materials analysis for biomedical and industrial applications.
