23-25 September 2013
Elite Gateway Hotel Ideon
Europe/Stockholm timezone

MicroMax Workshop

The Future of  Microfocus Protein Crystallography

Recent developments within protein crystallography methods in combination with the opportunities offered by the new upcoming synchrotron sources such as the MAX IV 3 GeV storage ring, make new exciting ways of carrying out research within structural biology possible. Small microfocus beamlines with a very high flux and increased coherence will make new types of experimentation possible.

The scientific possibilities will be highlighted through a series of talks by experts showing the impact of the new type of X-ray sources and microfocus beamlines on research within structural biology.

The new generation of microfocus beamlines will also set a high demand on instrumentation and suitable software. For example, data collection will potentially be very fast (in milliseconds) and radiation damage will allow only a limited amount of data to be collected from each sample. New technical solutions for sample handling and presentation, data processing methods and more will be needed for these types of experiments, and these will also be presented and discussed at the workshop.

The workshop is part of a process to obtain an updated proposal for the possible Phase 2b beamline MicroMAX. This workshop should give the user community an opportunity to explore the scientific possibilities of a new generation of microfocus beam lines, but it will also give them the chance to contribute with specific input on their own experimental demands on the beamline. The workshop is open for all.

Registration, Workshop Fees, Accommodation and Travel

The workshop is part of the MAX IV Laboratory user meeting. Register through the user meeting website. Latest day for registration is 13th September.


Session 1 Tuesday September 24th 13:00 to 18:15 - Room: TERA

Scientific Possibilities of Microfocus and Serial Microcrystallography

13:00 – 13:10
Jesper Andersen/Christoph Quitmann (MAX IV Laboratory)
13:10 – 13:15
Scope of the workshop
Richard Neutze (Gothenburg University)
13:15 – 14:00
Smaller, Faster, Better Microcrystallography - the New Normal
Janet Smith (Michigan University/APS)
14:05 – 14:35

Serial femtosecond crystallography vs. synchrotron microfocus
crystallography of GPCRs in lipidic cubic phase

Daniel Wacker (Scripps Research Institute, USA)
14:40 – 15:10

1 crystal, 5 datasets, 0.97 Å: phasing by S-SAD and segmented RIP
at ESRF ID29

Luca Jovine (Karolinska Institutet, Sweden)
15:10 – 15:30 Coffee break
15:30 – 16:00
The human histamine H1 receptor: small crystals with high impact
Simone Weyand (Cambridge University, UK)
16:05 – 16:35

Listeria Monocytogenes Lmo0818 – Exploring a putative
Ca2+-ATPase, to understand calcium ion specificity

Jens Preben Morth (Centre for Molecular Medicine, Norway) 
16:40 – 17:10

Microfocus and Serial Microcrystallography: An industrial
crystallography perspective

Tove Sjögren (AstraZeneca, Mölndal, Sweden)
17:15 – 17:45
Microcrystallography at MAX IV - what can we do?
Richard Neutze (Gothenburg University, Sweden)
17:45 – 18:15 General Discussion
19:00 – 22:00 Conference dinner

Session 2 Wednesday September 25th 08:30 to 12:30 - Room: TERA

Technical Solutions for Microfocus and Serial Microcrystallography

08:30 – 09:15
Pleasure in small things: Taking stock of Microfocus Experience
David Stuart (Oxford University / Diamond Light Source, UK)
09:20 – 09:50
Future plans for micro-crystallography at beamline P11 at PETRA III
Alke Meents (DESY, Hamburg, Germany)
09:55 – 10:25
Acoustic specimen preparation and delivery for next generation x-ray sources
Alexei Soares (NSLS-II Brookhaven, USA) 
10:25 – 10:45 Coffee Break
10:45 – 11:15
Data quality from serial crystallography
Thomas White (DESY, Hamburg, Germany)
11:20 – 11:50
Micro-focus beamline instrumentation and operation
Clemens Schulze-Briese (Dectris, Switzerland)  
11:55 – 12:30 Plans for MicroMAX and General Discussion
12:30 Lunch

Organized by: 

Richard Neutze, Gothenburg University 
Gunter Schneider, Karolinska Institute 
Gregers Rom Andersen, University of Aarhus